Multilevel Coding Schemes for Compute-and-Forward with Flexible Decoding

We consider the design of coding schemes for the wireless two-way relaying channel when there is no channel state information at the transmitter. In the spirit of the compute and forward paradigm, we present a multilevel coding scheme that permits computation (or, decoding) of a class of functions at the relay. The function to be computed (or, decoded) is then chosen depending on the channel realization. We define such a class of functions which can be decoded at the relay using the proposed coding scheme and derive rates that are universally achievable over a set of channel gains when this class of functions is used at the relay. We develop our framework with general modulation formats in mind, but numerical results are presented for the case where each node transmits using the QPSK constellation. Numerical results with QPSK show that the flexibility afforded by our proposed scheme results in substantially higher rates than those achievable by always using a fixed function or by adapting the function at the relay but coding over GF(4).Comment: This paper was submitted to IEEE Transactions on Information Theory in July 2011. A shorter version also appeared in the proceedings of the International Symposium on Information Theory in August 2011 without the proof of the main theore

Joint Compute and Forward for the Two Way Relay Channel with Spatially Coupled LDPC Codes

We consider the design and analysis of coding schemes for the binary input two way relay channel with erasure noise. We are particularly interested in reliable physical layer network coding in which the relay performs perfect error correction prior to forwarding messages. The best known achievable rates for this problem can be achieved through either decode and forward or compute and forward relaying. We consider a decoding paradigm called joint compute and forward which we numerically show can achieve the best of these rates with a single encoder and decoder. This is accomplished by deriving the exact performance of a message passing decoder based on joint compute and forward for spatially coupled LDPC ensembles.Comment: This paper was submitted to IEEE Global Communications Conference 201

Robustness of Compressed Sensing in Sensor Networks

Compressed sensing is a new theory that is based on the fact that many natural images can be sparsely represented in an orthonormal wavelet basis. This theory holds valuable implications for wireless sensor networks because power and bandwidth are limited resources. Applying the theory of compressed sensing to the sensor network data recovery problem, we describe a measurement scheme by which sensor network data can be compressively sampled and reconstructed. Then we analyze the robustness of this scheme to channel noise and fading coefficient estimation error. We demonstrate empirically that compressed sensing can produce significant gains for sensor network data recovery in both ideal and noisy environments

Coding Schemes for Physical Layer Network Coding Over a Two-Way Relay Channel

We consider a two-way relay channel in which two transmitters want to exchange information through a central relay. The relay observes a superposition of the trans- mitted signals from which a function of the transmitted messages is computed for broadcast. We consider the design of codebooks which permit the recovery of a function at the relay and derive information-theoretic bounds on the rates for reliable decoding at the relay. In the spirit of compute-and-forward, we present a multilevel coding scheme that permits reliable computation (or, decoding) of a class of functions at the relay. The function to be decoded is chosen at the relay depending on the channel realization. We define such a class of reliably computable functions for the proposed coding scheme and derive rates that are universally achievable over a set of channel gains when this class of functions is used at the relay. We develop our framework with general modulation formats in mind, but numerical results are presented for the case where each node transmits using 4-ary and 8-ary modulation schemes. Numerical results demonstrate that the flexibility afforded by our proposed scheme permits substantially higher rates than those achievable by always using a fixed function or considering only linear functions over higher order fields. Our numerical results indicate that it is favorable to allow the relay to attempt both compute-and-forward and decode-and-forward decoding. Indeed, either method considered separately is suboptimal for computation over general channels. However, we obtain a converse result when the transmitters are restricted to using identical binary linear codebooks generated uniformly at random. We show that it is impossible for this code ensemble to achieve any rate higher than the maximum of the rates achieved using compute-and-forward and decode-and-forward decoding. Finally, we turn our attention to the design of low density parity check (LDPC) ensembles which can practically achieve these information rates with joint-compute- and-forward message passing decoding. To this end, we construct a class of two-way erasure multiple access channels for which we can exactly characterize the performance of joint-compute-and-forward message passing decoding. We derive the processing rules and a density evolution like analysis for several classes of LDPC ensembles. Utilizing the universally optimal performance of spatially coupled LDPC ensembles with message passing decoding, we show that a single encoder and de- coder with puncturing can achieve the optimal rate region for a range of channel parameters

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research